What is Poloxamer 407 ？

Poloxamer 407, also known as Pluronic F127, is a nonionic surfactant, a type of chemical compound that has both hydrophobic (water-repelling) and hydrophilic (water-attracting) properties. It is made up of a central hydrophobic polypropylene oxide (PPO) block and two hydrophilic polyethylene oxide (PEO) blocks.

Poloxamer 407 is used in a variety of industrial and medical applications. In industry, it is used as a thickening agent, emulsifier, and lubricant. In medicine, it is used as a vehicle for drug delivery, as a lubricant for certain medical procedures, and as a surfactant in certain types of inhalation therapy.

In addition, Poloxamer 407 is used in cosmetics, personal care products, and other consumer products such as toothpaste, shampoo and many more. Its ability to form a gel-like consistency at low concentrations and its biocompatibility makes it a suitable ingredient in many formulations.

It’s worth noting that Poloxamer 407 is considered safe for most people when used as directed, but it may cause skin irritation in some individuals and more research is needed to confirm its safety. As always, it’s important to talk to a healthcare professional before using any new product.

 

How to made Poloxamer 407？

Poloxamer 407, also known as Pluronic F127, is typically made through a process called polymerization. This is a chemical process that involves the joining of small molecules called monomers to form larger molecules called polymers.

The process of making Poloxamer 407 typically involves the following steps:

• The monomers, polypropylene oxide (PPO) and polyethylene oxide (PEO), are synthesized separately.
• The PPO and PEO monomers are then mixed together in the presence of a catalyst, and heat and pressure are applied.
• The mixture undergoes polymerization, resulting in the formation of the Poloxamer 407 polymer.
• The polymer is then purified and dried to remove any impurities, and the resulting powder is packaged and stored.
• It’s important to note that the process of making Poloxamer 407 is complex and it should be done under the guidance of a trained professional using appropriate laboratory equipment and safety protocols. The purity and quality of the final product can be affected by many factors, including the starting materials and the methods used for polymerization and purification.

It’s also worth noting that poloxamers like Poloxamer 407 are synthetic polymers, and the manufacturing process of these polymers can vary depending on the company and the specific product. Due to the complexity of the synthesis, the product quality could be affected by many factors.

 

Extract method of Poloxamer 407？

Poloxamer 407 is a synthetic polymer, it is not extracted from natural sources, but is made through a process called polymerization. The process of making Poloxamer 407 typically involves the following steps:

• The monomers, polypropylene oxide (PPO) and polyethylene oxide (PEO), are synthesized separately.
• The PPO and PEO monomers are then mixed together in the presence of a catalyst, and heat and pressure are applied.
• The mixture undergoes polymerization, resulting in the formation of the Poloxamer 407 polymer.
• The polymer is then purified and dried to remove any impurities, and the resulting powder is packaged and stored.

It’s important to note that the process of making Poloxamer 407 is complex and it should be done under the guidance of a trained professional using appropriate laboratory equipment and safety protocols. The purity and quality of the final product can be affected by many factors, including the starting materials and the methods used for polymerization and purification.

Poloxamer 407 is not extracted from natural sources, but is made through chemical synthesis. It’s important to note that poloxamers like Poloxamer 407 are synthetic polymers, and the manufacturing process of these polymers can vary depending on the company and the specific product. Due to the complexity of the synthesis, the product quality could be affected by many factors.

 

Appearance of Poloxamer 407？

Poloxamer 407 is typically a white, powdery solid that is free-flowing and has no odor. The powder is usually packaged in airtight containers to maintain freshness and purity. It is a nonionic surfactant, which means it has the ability to lower the surface tension of liquids and can act as a wetting agent, emulsifier and a thickener. It can form a gel-like consistency at low concentrations depending on the temperature and concentration.

It’s worth noting that the appearance of Poloxamer 407 alone is not a reliable indicator of purity or quality, and a laboratory analysis is usually required to confirm the identity and purity of this compound. The color, texture, and other physical characteristics of the powder may vary depending on the source and the manufacturing process.

It’s important to note that Poloxamer 407 should be stored in a cool, dry place and away from light. It’s also important to check the expiration date and make sure to buy from a reputable source.

 

Active ingredient of Poloxamer 407？

The active ingredient in Poloxamer 407 is the polymer itself, a copolymer of polypropylene oxide and polyethylene oxide, it is a nonionic surfactant, which means it has the ability to lower the surface tension of liquids and can act as a wetting agent, emulsifier and a thickener. It is composed of a central hydrophobic polypropylene oxide (PPO) block and two hydrophilic polyethylene oxide (PEO) blocks. It is used in a variety of industrial and medical applications.

In industry, it is used as a thickening agent, emulsifier, and lubricant. In medicine, it is used as a vehicle for drug delivery, as a lubricant for certain medical procedures, and as a surfactant in certain types of inhalation therapy. In addition, Poloxamer 407 is used in cosmetics, personal care products, and other consumer products such as toothpaste, shampoo and many more. Its ability to form a gel-like consistency at low concentrations and its biocompatibility makes it a suitable ingredient in many formulations.

It’s important to note that the effectiveness of Poloxamer 407 may depend on the purity and quality of the product, and it’s important to talk to a healthcare professional before using any new product.

 

What Is Poloxamer 407 Used For？

Poloxamer 407, also known as Pluronic F127, is a nonionic surfactant that is used for several industrial and medical purposes:

• Industrial uses: Poloxamer 407 is used as a thickening agent, emulsifier and lubricant in various industrial applications such as in textile, paint, and printing ink industries.
• Medical uses: Poloxamer 407 is used as a vehicle for drug delivery, as a lubricant for certain medical procedures, and as a surfactant in certain types of inhalation therapy. It is also used as a lubricant for ophthalmic surgery and as an excipient in the formulation of oral and injectable drugs.
• Personal care and cosmetics: Poloxamer 407 is also used in cosmetics, personal care products, and other consumer products such as toothpaste, shampoo and many more. Its ability to form a gel-like consistency at low concentrations and its biocompatibility makes it a suitable ingredient in many formulations.

It’s worth noting that the effectiveness of Poloxamer 407 may depend on the purity and quality of the product and more research is needed to confirm its safety and effectiveness. As always, it’s important to talk to a healthcare professional before using any new product.

 

What the feature of Poloxamer 407？

Poloxamer 407, also known as Pluronic F127, is a nonionic surfactant that has several features that make it unique and beneficial for various industrial and medical applications:

• Surface activity: Poloxamer 407 has the ability to lower the surface tension of liquids and can act as a wetting agent, emulsifier and a thickener.
• Temperature responsive: Poloxamer 407 can form a gel-like consistency at low concentrations depending on the temperature and concentration.
• Biocompatibility: Poloxamer 407 is biocompatible, which means it does not cause any adverse reactions when used in contact with living tissue or cells.
• Versatile: Poloxamer 407 has a wide range of industrial and medical applications, including drug delivery, lubrication, and as an excipient in pharmaceutical formulations.
• Non-toxic: Poloxamer 407 is considered to be non-toxic in general.

It’s worth noting that the effectiveness of Poloxamer 407 may depend on the purity and quality of the product and more research is needed to confirm its safety and effectiveness. As always, it’s important to talk to a healthcare professional before using any new product and to be aware of the proper handling and storage of this chemical.

 

Chemical constituents of Poloxamer 407？

Poloxamer 407 is a synthetic polymer, it is a copolymer made of polypropylene oxide (PPO) and polyethylene oxide (PEO) monomers. The polymer is composed of a central hydrophobic polypropylene oxide (PPO) block and two hydrophilic polyethylene oxide (PEO) blocks. The PPO block provides the polymer with its hydrophobic properties, while the PEO blocks provide the polymer with its hydrophilic properties. The ratio of PPO to PEO in Poloxamer 407 is typically around 20:80. This chemical composition gives Poloxamer 407 its unique properties as a surfactant, thickening and emulsifying agent.

It’s worth noting that the chemical composition of Poloxamer 407 can vary depending on the source and the manufacturing process. The purity and quality of the final product can be affected by many factors, including the starting materials and the methods used for polymerization and purification. Poloxamer 407 is a synthetic polymer, and the manufacturing process of these polymers can vary depending on the company and the specific product. Due to the complexity of the synthesis, the product quality could be affected by many factors.

By Lin From Chinese Natural Plant Extracts  l Herb Extracts l Cosmetic Ingredients l Food Ingredients l Fruit & Vegetable Powder l Nutritional Supplements Manufacturer Shanghai Plant Biotechnology Co., Ltd